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MA1-760 detects nonspecific cytotoxic cells (NCC) from catfish and tilapia tissues and also detects natural killer/lymphokine activated killer (NK/LAK) cells from rat, bovine, equine, canine and porcine tissues. MA1-760 has been successfully used in Western blot, cytotoxic inhibition studies with NCC/NK/LAK cells, FACS, immunoprecipitation, panning, and ELISA procedures. By Western blot, this antibody detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein. In cytotoxicity assays, this antibody is used under saturating conditions to inhibit target cell conjugation. The MA1-760 immunogen is purified NCC cells from catfish.
Non-specific cytotoxic cells (NCCs) in teleosts and their evolutionary homologue are a subpopulation of lymphocytes with properties that distinguish them from either B- or T-cells. One such property is that NCC/natural killer (NK)/lymphokine activated killer (LAK) cells express spontaneous, non-major histocompatibility complex restricted cytotoxic activity. NCC and LAK lyse a variety of transformed murine and human B-cell, T-cell and myeloid targets. A 32 kDa membrane protein [non-specific cytotoxic cell receptor protein (NCCRP-1)] expressed by NCC and certain mammalian NK/LAK cells mediates this cytotoxicity. NCCRP-1 is evolutionarily conserved and is found in species ranging from marine and freshwater teleosts to higher mammals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Natural Killer Cell; NCC/NK