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Invitrogen
Noto Polyclonal Antibody
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Product Details
PA5-143403
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of zebrafish Flh. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
sequence-specific DNA binding
heart looping
determination of left/right asymmetry in lateral mesoderm
embryonic heart tube morphogenesis
endocardium morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
determination of left/right symmetry
central nervous system development
notochord formation
floor plate formation
pineal gland development
neuron differentiation
adrenal gland development
notochord development
glomerulus development
floor plate development
embryonic heart tube development
pronephric glomerulus morphogenesis
developmental pigmentation
axial mesoderm morphogenesis
axial mesodermal cell fate specification
axial mesoderm structural organization
notochord cell differentiation
somite development
determination of heart left/right asymmetry
regulation of BMP signaling pathway involved in heart jogging
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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