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Invitrogen
Nrf2 Polyclonal Antibody
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FIGURE: 1 / 5
Nrf2 Antibody (PA5-120048) in IHC (P)
Immunohistochemistry analysis of Nrf2 in paraffin-embedded human breast cancer using. Samples were incubated with Nrf2 Polyclonal antibody (Product # PA5-120048) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-120048
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.92 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SPHFLNAFED SFSSILSTED PNQLTVNSLN SDATVNTDFG DEFYSAFIAE PSISNSMPSP ATLSHSLSEL LNGPIDVSDL SLCKAFNQNH PESTAEFNDS DSGISLNTSP SVASPEHSVE SSSYGDTLLG LSDSEVEELD SAPGSVKQNG PKTPVHSS
Positive test controls include: HeLa, NIH/3T3. The target is usually found in the following locations: Cytoplasm, Nucleus, cytosol.
Target Information
Nfr1 (also designated TCF11), Nrf2 and Nfr3 are bZIP transcription factors that heterodimer with Maf proteins to bind MARE (Maf recognition elements) sequences. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E4TF1-60; E4TF1A; NF-E2-related factor 2; NFE2-related factor 2; NFT2; nrf2; NRF2A; nuclear factor erythroid 2-like 2; Nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2-like 2; Nuclear factor, erythroid derived 2, like 2
Gene Aliases: AI194320; HEBP1; NFE2L2; NRF2
UniProt ID: (Human) Q16236, (Mouse) Q60795, (Rat) O54968
Entrez Gene ID: (Human) 4780, (Mouse) 18024, (Rat) 83619
transcription regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription cofactor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
transcription regulatory region DNA binding
sequence-specific DNA binding
protein heterodimerization activity
basic leucine zipper transcription factor
transcription from RNA polymerase II promoter
inflammatory response
proteasomal ubiquitin-independent protein catabolic process
positive regulation of gene expression
protein ubiquitination
positive regulation of blood coagulation
endoplasmic reticulum unfolded protein response
cellular response to oxidative stress
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
proteasome-mediated ubiquitin-dependent protein catabolic process
cell redox homeostasis
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
positive regulation of glucose import
cellular response to hydrogen peroxide
cellular response to tumor necrosis factor
cellular response to fluid shear stress
cellular response to laminar fluid shear stress
negative regulation of hematopoietic stem cell differentiation
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of hydrogen peroxide-induced cell death
positive regulation of glutathione biosynthetic process
regulation of removal of superoxide radicals
negative regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
response to endoplasmic reticulum stress
positive regulation of transcription, DNA-templated
negative regulation of cell death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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