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NeoBiotechnologies
Nucleoside Diphosphate Kinase A/nm23-H1 Monoclonal Antibody (NME1/2737)
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产品信息
4830-MSM7-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
NME1/2737
抗原
Recombinant full-length human NME1 protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in the gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis secretory sperm binding protein; Farnesyl diphosphate kinase NME1; GAAD; Granzyme A activated DNase (GAAD); granzyme A-activated DNase; GZMA activated DNase; Histidine protein kinase NME1; included; Metastasis inhibition factor nm23; NDK1; NDP kinase A; NM23-H1; NM23H1; NM23H1B; NME1; NME1-NME2 spliced read-through transcript; non-metastatic cells 1, protein (NM23A) expressed in; Non-specific serine/threonine protein kinase NME1; Nucleoside diphoshate kinase 1; Nucleoside diphosphate kinase A; Putative 3'-5'-DNA exonuclease NDK1; Putative granzyme A-activated DNA endonuclease; Tumor metastatic process-associated protein; unnamed protein product
基因别名: AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1; NME1
UniProt ID: (Human) P15531
Entrez Gene ID: (Human) 4830
nucleotide binding
magnesium ion binding
DNA binding
RNA binding
endodeoxyribonuclease activity
deoxyribonuclease activity
nucleoside diphosphate kinase activity
protein histidine kinase activity
protein binding
ATP binding
3'-5'-exodeoxyribonuclease activity
kinase activity
transferase activity
phosphotransferase activity, phosphate group as acceptor
GDP binding
identical protein binding
ribosomal small subunit binding
ADP binding
metal ion binding
farnesyl diphosphate kinase activity
coenzyme A binding
succinyl-CoA binding
acetyl-CoA binding
GTP biosynthetic process
UTP biosynthetic process
CTP biosynthetic process
DNA catabolic process
apoptotic DNA fragmentation
isoprenoid metabolic process
endocytosis
nervous system development
lactation
negative regulation of cell proliferation
nucleotide metabolic process
nucleoside diphosphate metabolic process
nucleoside triphosphate biosynthetic process
cell differentiation
mammary gland development
protein hexamerization
regulation of fatty acid biosynthetic process
regulation of apoptotic process
ITP biosynthetic process
acetyl-CoA catabolic process
positive regulation of epithelial cell proliferation
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