Fabgennix

Nurr1 Polyclonal Antibody, FITC

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问题与答案

问题与答案

问题与答案

Additional Information:

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产品信息

NURR1-FITC

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化 (IHC)

1:50-1:250

-

酶联免疫吸附实验 (ELISA)

1:10,000

-

免疫沉淀 (IP)

1:50-1:250

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acid region 566-591. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker. Sequence:CTQGLQRIFYLKLEDLVPPPAIIDKL

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The Nuclear receptor related 1 protein (Nurr1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene. NURR1 is a member of the nuclear receptor family of intracellular transcription factors.Nurr1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HZF3; Immediate-early response protein NOT; NGFI-B; NGFI-B beta; Nuclear receptor subfamily 4 group A member 2; nur related protein 1; NUR-related factor 1; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor

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基因别名: HZF-3; NOT; NR4A2; NURR1; RNR-1; TINOR; TINUR

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UniProt ID: (Mouse) Q06219

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Entrez Gene ID: (Mouse) 18227

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RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding sequence-specific DNA binding metal ion binding protein heterodimerization activity C4 zinc finger nuclear receptor

response to hypoxia neuron migration response to amphetamine transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter nervous system development adult locomotory behavior post-embryonic development response to inorganic substance gene expression regulation of gene expression obsolete death response to insecticide central nervous system projection neuron axonogenesis central nervous system neuron differentiation habenula development neuron differentiation intracellular receptor signaling pathway cellular response to extracellular stimulus cellular response to oxidative stress regulation of dopamine metabolic process dopamine biosynthetic process dopamine metabolic process neuron maturation positive regulation of catalytic activity steroid hormone mediated signaling pathway negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter general adaptation syndrome dopaminergic neuron differentiation