Invitrogen

OAS3 Polyclonal Antibody

Name: OAS3 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-97217

高级验证

查看其他6个OAS3抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (4)
高级验证 (1)

OAS3 Antibody in Immunocytochemistry (ICC/IF)

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OAS3 Antibody (PA5-97217) in ICC/IF

Immunofluorescence analysis of OAS3 in U-2 OS cells. Samples were incubated with OAS3 Polyclonal antibody (Product # PA5-97217) using a dilution of 1:100. Blue: DAPI for nuclear staining.

Product Image Gallery

OAS3 Antibody — Altered expression of proteins upon cell treatment demonstrates antibody specificity. Western blot using OAS3 Polyclonal Antibody (Product # PA5-97217), shows upregulation in OAS3 expression upon IFN beta 1A treatment in A549, and IFN alpha A treatment in HT-1080 and HeLa (https://doi.org/10.1073/pnas.1519657113). {TM}

Immunogen image

Immunogen Image OAS3 Polyclonal Antibody

产品信息

PA5-97217

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:100-1:200

免疫细胞化学 (ICC/IF)

1:50-1:200

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein (or fragment)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.62 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2809019

产品详细信息

Immunogen sequence: AASCYDHPCF LRGMGDPVQS WKGPGLPRAG CSGLGHPIQL DPNQKTPENS KSLNAVYPRA GSKPPSCPAP GPTGAASIVP SVPGMALDLS QIPTKELDRF IQDHLKPSPQ FQEQVKKAID IILRCLHENC VHKASRVSKG GSFGRGTDLR DGCDVELIIF LNCFTDYKDQ GPRRAEILDE MRAQLESWWQ DQVPSLSLQF PEQNVPEALQ FQLVSTALKS WTDVSLLPAF DAVGQLSSGT KPNPQVYSRL LTSGCQEGEH KACFAELRRN FMNIRPVKLK NLILLVKHWY RQVAAQNKGK G; Positive Samples: U-87MG, DU145, HeLa; Cellular Location: Cytoplasm, Nucleus

靶标信息

OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: (2-5')oligo(A) synthase 3; (2-5')oligo(A) synthetase 3; 2',5'-oligoadenylate synthetase-like 10; 2'-5' oligoadenylate synthetase-like 10; 2'-5'-oligoadenylate synthase 3; 2'-5'-oligoadenylate synthetase 3, 100kDa; 2'-5'oligoadenylate synthetase p100; 2-5A synthase 3; 2-5A synthetase 3; p100 OAS; p100OAS

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基因别名: OAS3; Oasl10; P/OKcl.4; p100; p100OAS

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UniProt ID: (Human) Q9Y6K5, (Rat) Q5MYT7, (Mouse) Q8VI93

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Entrez Gene ID: (Human) 4940, (Rat) 494202, (Mouse) 246727

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