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Invitrogen
OCT4 Polyclonal Antibody
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Product Details
PA5-72181
Product Specifications
Species Reactivity
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 128-161 amino acids from the N-terminal region of human DANRE pou5f1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
POU5F1, also commonly known as Oct-4, is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. The role of POU5F1 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing POU5F1, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-Oct; 4-Oct; DADB-104B20.2; gp-9; HGNC:9221; MGC22487; OTTHUMP00000221150; OTTHUMP00000221151; POU domain gene 2; POU domain protein 2; POU domain, class 5, transcription factor 1; pou-2; pou2; spiel-ohne-grenzen; spiel-ohne-grenzen/pou2
Gene Aliases: cb197; chunp6868; etID49452.21; gp-9; gp9; oct4; POU-2; pou2; pou5f1; spg; spg/pou2; wu:fd18d06
UniProt ID: (Zebrafish) Q90270
Entrez Gene ID: (Zebrafish) 30333
endoderm formation
regulation of transcription, DNA-templated
multicellular organism development
ectoderm development
brain development
mesoderm development
anatomical structure morphogenesis
embryonic pattern specification
dorsal/ventral pattern formation
regulation of gene expression
morphogenesis of embryonic epithelium
cell differentiation
hindbrain development
midbrain-hindbrain boundary development
fin regeneration
nucleosome organization
brain segmentation
regulation of endodermal cell fate specification
regulation of DNA methylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
epiboly involved in gastrulation with mouth forming second
epiboly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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