Product References
Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency.
Disease models & mechanisms
Niceforo A,Marioli C,Colasuonno F,Petrini S,Massey K,Tartaglia M,Bertini E,Moreno S,Compagnucci C
MA5-14845 was used in Immunocytochemistry-Immunofluorescence to show that RF administration resulted in partially improved cytoskeletal features in patients' iPSCs and MNs.
Tue Jan 19 00:00:00 EST 2021
Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency.
Disease models & mechanisms
Niceforo A,Marioli C,Colasuonno F,Petrini S,Massey K,Tartaglia M,Bertini E,Moreno S,Compagnucci C
MA5-14845 was used in Immunocytochemistry-Immunofluorescence to show that RF administration resulted in partially improved cytoskeletal features in patients' iPSCs and MNs.
Tue Jan 19 00:00:00 EST 2021
Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating.
PeerJ
Salerno JA,Torquato T,Temerozo JR,Goto-Silva L,Karmirian K,Mendes MA,Sacramento CQ,Fintelman-Rodrigues N,Souza LRQ,Ornelas IM,Veríssimo CP,Aragão LGHS,Vitória G,Pedrosa CSG,da Silva Gomes Dias S,Cardoso Soares V,Puig-Pijuan T,Salazar V,Dariolli R,Biagi D,Furtado DR,Barreto Chiarini L,Borges HL,Bozza PT,Zaluar P Guimarães M,Souza TML,Rehen SK
MA5-14845 was used in Flow Cytometry to investigated the consequences of the inhibition of the Sigma-1 receptor, a ubiquitously expressed chaperone that plays a central role in cardiomyocyte function, in iPSC-derived human cardiomyocytes on the basis that it may affect SARS-CoV-2 replication.
Wed Nov 08 00:00:00 EST 2023
Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.
Nature communications
Ajiro M,Awaya T,Kim YJ,Iida K,Denawa M,Tanaka N,Kurosawa R,Matsushima S,Shibata S,Sakamoto T,Studer L,Krainer AR,Hagiwara M
MA5-14845 was used in Immunocytochemistry to indicate that small synthetic molecules affecting phosphorylation state of SRSFs is available as a new therapeutic modality for mechanism-oriented precision medicine of splicing diseases.
Fri Jul 23 00:00:00 EDT 2021
Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.
Cells
Goričan L,Gole B,Potočnik U
MA5-14845 was used in Western Blotting to develop a cancer stem cell (CSC)-enriched spheroid model with a simple protocol, a microplate format compatible with multimodal detection systems, and a high detection signal, making it suitable for anti-CSC compounds' high-throughput screening (HTS).
Thu Jul 16 00:00:00 EDT 2020
Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.
Cells
Goričan L,Gole B,Potočnik U
MA5-14845 was used in Western Blotting to develop a cancer stem cell (CSC)-enriched spheroid model with a simple protocol, a microplate format compatible with multimodal detection systems, and a high detection signal, making it suitable for anti-CSC compounds' high-throughput screening (HTS).
Thu Jul 16 00:00:00 EDT 2020
Human Cardiac Organoids for Modeling Genetic Cardiomyopathy.
Cells
Filippo Buono M,von Boehmer L,Strang J,Hoerstrup SP,Emmert MY,Nugraha B
MA5-14845 was used in Flow cytometry/Cell sorting to demonstrate the generation of cardiac organoids using a triculture approach of human induced pluripotent stem-cell-derived cardiomyocytes (hiPS-CMs)- from healthy subjects and cardiomyopathy patients-human cardiac microvascular endothelial cells (HCMECs) and human cardiac fibroblasts (HCFs).
Mon Jul 20 00:00:00 EDT 2020
Human Cardiac Organoids for Modeling Genetic Cardiomyopathy.
Cells
Filippo Buono M,von Boehmer L,Strang J,Hoerstrup SP,Emmert MY,Nugraha B
MA5-14845 was used in Flow cytometry/Cell sorting to demonstrate the generation of cardiac organoids using a triculture approach of human induced pluripotent stem-cell-derived cardiomyocytes (hiPS-CMs)- from healthy subjects and cardiomyopathy patients-human cardiac microvascular endothelial cells (HCMECs) and human cardiac fibroblasts (HCFs).
Mon Jul 20 00:00:00 EDT 2020