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Invitrogen
OGG1 Polyclonal Antibody
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FIGURE: 1 / 7
OGG1 Antibody (PA1-16505) in ICC/IF
Immunocytochemistry analysis of OGG1 in A431 cells. Samples were incubated with OGG1 polyclonal antibody (Product # PA1-16505) using a dilution of 1:200 dilution overnight at 4°C followed by anti-rabbit Dylight 488 (Green) at a dilution of 1:500. Cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. Alpha Tubulin (DM1A) was used as a co-stain at a 1:1,000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Bl... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-16505
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide derived from human Ogg1 (within amino acids 1-100).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: Jurkat whole cell extracts.
Target Information
8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26. 2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; N-glycosylase/DNA lyase
Gene Aliases: MMH; MUTM; OGG1; OGH1
UniProt ID: (Mouse) O08760, (Rat) O70249
Entrez Gene ID: (Pig) 100155036, (Rabbit) 103345505, (Mouse) 18294, (Rat) 81528
purine-specific mismatch base pair DNA N-glycosylase activity
oxidized base lesion DNA N-glycosylase activity
DNA binding
damaged DNA binding
catalytic activity
DNA-(apurinic or apyrimidinic site) lyase activity
uracil DNA N-glycosylase activity
microtubule binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
lyase activity
single-strand selective uracil DNA N-glycosylase activity
DNA N-glycosylase activity
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DNA-3-methylbase glycosylase activity
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
DNA metabolism protein
DNA repair
base-excision repair
nucleotide-excision repair
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
response to oxidative stress
aging
metabolic process
response to radiation
response to estradiol
regulation of protein import into nucleus, translocation
nucleotide-excision repair, DNA incision
negative regulation of apoptotic process
nucleic acid phosphodiester bond hydrolysis
negative regulation of double-strand break repair via single-strand annealing
DNA catabolic process, endonucleolytic
acute inflammatory response
response to light stimulus
response to drug
response to ethanol
response to folic acid
cellular response to cadmium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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