Invitrogen

OLIG2 Polyclonal Antibody

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OLIG2 Antibody (P21954) in WB

Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~32 kDa Olig2 protein.

OLIG2 Antibody in Immunohistochemistry (IHC)

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产品信息

P21954

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

免疫组化 (IHC)

Assay-dependent

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免疫组化（冰冻） (IHC (F))

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流式细胞分析 (Flow)

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免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant mouse Olig2.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

purified

保存液

0.2M tris, pH 8, with 0.1M glycine

内含物

no preservative

保存条件

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2539836

靶标信息

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Impaired Oligodendrocyte Maturation Is an Early Feature in SCA3 Disease Pathogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Schuster KH,Zalon AJ,Zhang H,DiFranco DM,Stec NR,Haque Z,Blumenstein KG,Pierce AM,Guan Y,Paulson HL,McLoughlin HS

P21954 was used in Immunohistochemistry to provide evidence for severe dysfunction in oligodendrocyte maturation early in SCA3 pathogenesis.

Wed Feb 23 00:00:00 EST 2022

Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence.

Communications biology

Pan JX,Sun D,Lee D,Xiong L,Ren X,Guo HH,Yao LL,Lu Y,Jung C,Xiong WC

P21954 was used in Immunohistochemistry to show that TgAPPsweOCN mice also exhibit Alzheimer's disease-relevant brain pathologies and behavior phenotypes.

Thu Nov 25 00:00:00 EST 2021

Lentiviral-Induced Spinal Cord Gliomas in Rat Model.

International journal of molecular sciences

Nagarajan PP,Tora MS,Neill SG,Federici T,Texakalidis P,Donsante A,Canoll P,Lei K,Boulis NM

P21954 was used in Immunohistochemistry to evaluate the ability of each vector alone and combinations of vectors to produce high-grade spinal cord gliomas.

Tue Nov 30 00:00:00 EST 2021

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.

Cell

Nguyen PT,Dorman LC,Pan S,Vainchtein ID,Han RT,Nakao-Inoue H,Taloma SE,Barron JJ,Molofsky AB,Kheirbek MA,Molofsky AV

P21954 was used in Flow Cytometry to study a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation.

Thu Jul 23 00:00:00 EDT 2020

Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy.

Acta neuropathologica communications

Dhillon RS,Parker J,Syed YA,Edgley S,Young A,Fawcett JW,Jeffery ND,Franklin RJ,Kotter MR

P21954 was used in immunohistochemistry - frozen section test if axonal plasticity contributes to recovery following surgical decompression

Tue Aug 23 00:00:00 EDT 2016

TREM2 sustains microglial expansion during aging and response to demyelination.

The Journal of clinical investigation

Poliani PL,Wang Y,Fontana E,Robinette ML,Yamanishi Y,Gilfillan S,Colonna M

Published figure using OLIG2 polyclonal antibody (Product # P21954) in Immunohistochemistry

Fri May 01 00:00:00 EDT 2015

生物信息学

蛋白别名: basic domain, helix-loop-helix protein, class B, 1; Basic helix loop helix protein class B1 (bHLHB1); basic helix-loop-helix protein 19 (bHLHe19); bHLHb1; bHLHe19; Class B basic helix-loop-helix protein 1; Class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; olig-2; Oligo2; Oligo2 antibody; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein 2; Protein kinase C-binding protein 2 (PRKCBP2); Protein kinase C-binding protein RACK17

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基因别名: AI604895; BHLHB1; BHLHE19; Olg-2; OLIG2; OLIGO2; PRKCBP2; RACK17; RK17

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UniProt ID: (Human) Q13516, (Mouse) Q9EQW6

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Entrez Gene ID: (Human) 10215, (Mouse) 50913, (Rat) 304103

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功能

DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein homodimerization activity HMG box domain binding transcription factor activity, sequence-specific DNA binding protein binding protein dimerization activity basic helix-loop-helix transcription factor

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