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Invitrogen
OXPAT Polyclonal Antibody
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FIGURE: 1 / 8
OXPAT Antibody (PA5-114352) in IHC (P)
Immunohistochemical analysis of OXPAT in paraffin-embedded mouse heart tissue using a polyclonal antibody (Product #PA5-114352). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:100) for 30 minutes a... View More
Product Details
PA5-114352
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human Perilipin-5 aa 80-302
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: lipid droplet associated protein; Lipid droplet-associated protein PAT-1; Lipid storage droplet protein 5; Myocardial LD protein; Perilipin-5
Gene Aliases: 2310076L09Rik; AI415325; AW109675; LSDA5; LSDP5; MLDP; OXPAT; PAT-1; Pat1; PLIN5
UniProt ID: (Human) Q00G26, (Mouse) Q8BVZ1
Entrez Gene ID: (Human) 440503, (Mouse) 66968
positive regulation of triglyceride biosynthetic process
positive regulation of lipid storage
positive regulation of sequestering of triglyceride
negative regulation of triglyceride catabolic process
lipid storage
negative regulation of fatty acid beta-oxidation
positive regulation of fatty acid beta-oxidation
lipid particle organization
negative regulation of peroxisome proliferator activated receptor signaling pathway
mitochondrion localization
negative regulation of lipase activity
positive regulation of lipase activity
negative regulation of reactive oxygen species metabolic process
lipid metabolic process
negative regulation of lipid catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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