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Invitrogen
Occludin Polyclonal Antibody
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产品信息
PA5-20755
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 15 amino acid peptide from near the carboxy terminus of human OCLN.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is human liver tissue lysate.
PA5-20755 can be used with blocking peptide PEP-0869.
Antibodies should not be exposed to prolonged high temperatures.
靶标信息
Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Occludin; phosphatase 1, regulatory subunit 115; tight junction protein occludin
基因别名: AI503564; BLCPMG; Ocl; OCLN; PPP1R115
UniProt ID: (Human) Q16625, (Mouse) Q61146, (Rat) Q6P6T5
Entrez Gene ID: (Human) 100506658, (Mouse) 18260, (Rat) 83497
