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Invitrogen
P2X2 Polyclonal Antibody
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P2X2 Antibody (PA5-119683) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human esophagus tissue using P2X2 Polyclonal Antibody (Product # PA5-119683). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the P2X2 antibody at a dilution of... View More
产品信息
PA5-119683
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within C-terminal mouse P2X2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: Mouse brain tissue lysates, rat brain tissue, human esophagus tissue, mouse brain tissue, MCF-7.
Subcellular Location: Cell membrane.
靶标信息
P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ATP receptor; MGC129601; P2X purinoceptor 2; P2X Receptor, subunit 2; P2X2; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 2; purinergic receptor P2X, ligand-gated ion channel, 2
基因别名: DFNA41; P2RX2; P2X2; P2X2a
UniProt ID: (Human) Q9UBL9, (Rat) P49653, (Mouse) Q8K3P1
Entrez Gene ID: (Human) 22953, (Rat) 114115, (Mouse) 231602
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
ATP binding
ligand-gated ion channel activity
identical protein binding
ion channel activity
copper ion binding
protein binding
drug binding
zinc ion binding
nickel cation binding
phosphatidylinositol binding
mercury ion binding
cadmium ion binding
cobalt ion binding
ligand-gated ion channel
response to hypoxia
detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
neuromuscular synaptic transmission
neuromuscular junction development
blood coagulation
sensory perception of sound
response to carbohydrate
positive regulation of calcium ion transport into cytosol
urinary bladder smooth muscle contraction
peristalsis
response to ATP
purinergic nucleotide receptor signaling pathway
behavioral response to pain
skeletal muscle fiber development
positive regulation of calcium-mediated signaling
sensory perception of taste
protein homooligomerization
cation transmembrane transport
cation transport
chemical synaptic transmission
response to organic substance
neuronal action potential
ion transmembrane transport
protein heterooligomerization
transport
ion transport
