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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • P2X7 Antibodies

          Alomone Labs, LTD

          P2X7 Receptor Polyclonal Antibody

          查看其他21个P2X7抗体

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          说明书
          实验方案
          问题与答案
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          说明书
          实验方案
          问题与答案
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          Cite P2X7 Receptor Polyclonal Antibody

          • 抗体检测数据 (2)
          P2X7 Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          P2X7 Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 2

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          P2X7 Receptor Antibody (APR-004-200UL) in IHC (P)

          Expression of P2X7 Receptorin rat pancreas - Immunohistochemical staining of rat paraffin-embedded endocrine and exocrine pancreas sections using Anti-P2X7 Receptor Antibody (#APR-004), (1:50), followed by goat Anti-rabbit-AlexaFluor-555-secondary Antibody (1:500), (red). Staining is highly specific for endocrine cells of theIsle of Langerhans.Hoechst 33342 is used as the counterstain (blue). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
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          查看产品

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          P2X7 Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          P2X7 Receptor Antibody in Western Blot (WB)
          P2X7 Receptor Polyclonal Antibody

          产品信息

          APR-004-200UL

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:200
          -

          免疫组化(石蜡) (IHC (P))

          1:50
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          (C)KIRKEFPKTQGQYSGFKYPY, corresponding to amino acid residues 576-595 of rat P2X7 receptor, Intracellular, C-terminus
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Lyophilized

          浓度

          0.6 mg/mL

          纯化类型

          Antigen affinity chromatography

          保存液

          PBS, pH 7.4, with 1% BSA

          内含物

          0.05% sodium azide

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          产品详细信息

          Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

          靶标信息

          The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7; purinergic receptor P2X7 variant A

          查看更多 收起

          基因别名: AI467586; P2RX7; P2X(7); P2X7; P2X7R

          查看更多 收起

          UniProt ID: (Human) Q99572, (Rat) Q64663, (Mouse) Q9Z1M0

          查看更多 收起

          Entrez Gene ID: (Human) 5027, (Rat) 29665, (Mouse) 18439

          查看更多 收起

          功能
          lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding protein binding ATP binding protein homodimerization activity magnesium ion binding receptor activity copper ion binding zinc ion binding channel activity protein serine/threonine kinase activator activity scaffold protein binding ion channel activity ligand-gated ion channel
          参与通路
          activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity regulation of sodium ion transport protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane membrane budding inflammatory response mitochondrion organization cell surface receptor signaling pathway blood coagulation response to mechanical stimulus response to zinc ion positive regulation of calcium ion transport into cytosol positive regulation of gene expression positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis NAD transport negative regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process positive regulation of cytolysis ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus regulation of killing of cells of other organism membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to dsRNA reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway positive regulation of bleb assembly positive regulation of protein phosphorylation cation transport calcium ion transport cell volume homeostasis plasma membrane organization response to bacterium response to organic substance gene expression programmed cell death response to organic cyclic compound organic cation transport neuronal action potential positive regulation of interleukin-1 beta production positive regulation of apoptotic process positive regulation of catalytic activity positive regulation of MAPK cascade positive regulation of ossification positive regulation of protein secretion positive regulation of cytokine secretion cellular response to organic cyclic compound cation transmembrane transport transport ion transport
          It has to be done as per old AB suggested Products section.
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