Invitrogen

PACAP-38 Polyclonal Antibody

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说明书
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
PACAP-38 Polyclonal Antibody

产品信息

PA5-143860

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.25-0.5 µg/mL
-

免疫组化（石蜡） (IHC (P))

2-5 µg/mL
-

流式细胞分析 (Flow)

1-3 µg/1x10^6 cells
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence of human PACAP-38/ADCYAP1 (QMAVKKYLAAVLGKRYKQRVK).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 4mg trehalose

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3075074

产品详细信息

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Positive Control - WB: human HEL whole cell. IHC: human lung cancer tissue. Flow: HEL cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: adenylate cyclase activating polypeptide 1 (pituitary); PACAP; pituitary adenylate cyclase activating polypeptide; Pituitary adenylate cyclase-activating polypeptide; prepro-PACAP

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基因别名: ADCYAP1; PACAP

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UniProt ID: (Human) P18509

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Entrez Gene ID: (Human) 116

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功能
receptor signaling protein activity receptor binding neuropeptide hormone activity protein binding pituitary adenylate cyclase activating polypeptide activity pituitary adenylate cyclase-activating polypeptide receptor binding peptide hormone receptor binding neuropeptide
参与通路
ovarian follicle development behavioral fear response histamine secretion negative regulation of acute inflammatory response to antigenic stimulus negative regulation of acute inflammatory response to non-antigenic stimulus activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway cell-cell signaling female pregnancy regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway negative regulation of muscle cell apoptotic process positive regulation of neuron projection development sensory perception of pain cAMP-mediated signaling pituitary gland development neuron projection development positive regulation of interleukin-6 production regulation of protein localization negative regulation of GTPase activity response to starvation negative regulation of potassium ion transport positive regulation of GTPase activity response to ethanol negative regulation of cell cycle positive regulation of protein kinase activity positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter ATP metabolic process positive regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential positive regulation of growth hormone secretion negative regulation of glial cell proliferation positive regulation of ERK1 and ERK2 cascade regulation of oligodendrocyte progenitor proliferation cellular response to glucocorticoid stimulus positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of somatostatin secretion
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