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Invitrogen
PACAP-38 Polyclonal Antibody
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PACAP-38 Antibody (PA5150473) in WB
Western blot analysis of PACAP-38 using: Lane 1: Marker [kDa] 250,130,95,72,55,36,28,17,10; Lane 2: RT4; Lane 3: U-251 MG; Lane 4: Human Plasma; Lane 5: Liver; Lane 6: Tonsil. Samples were incubated with PACAP-38 polyclonal antibody (Product # PA5150473).
产品信息
PA5150473
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence.
偶联物
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Highest antigen sequence identity to the following orthologs: Mouse- 80%, Rat- 76%.
Sequence of this protein is as follows: VLDQLSAGKH LQSLVARGVG GSLGGGAGDD AEPLSKRHSD GIFTDSYSRY RKQMA
靶标信息
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenylate cyclase activating polypeptide 1 (pituitary); PACAP; Pituitary adenylate cyclase-activating polypeptide; prepro-PACAP; unnamed protein product
基因别名: ADCYAP1; PACAP
UniProt ID: (Human) P18509
Entrez Gene ID: (Human) 116
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
cell-cell signaling
nervous system development
female pregnancy
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of gene expression
insulin secretion
neuron projection development
regulation of protein localization
positive regulation of GTPase activity
negative regulation of cell cycle
positive regulation of protein kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of growth hormone secretion
positive regulation of ERK1 and ERK2 cascade
positive regulation of chemokine (C-C motif) ligand 5 production
positive regulation of cold-induced thermogenesis
positive regulation of cAMP/PKA signal transduction
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