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PAK2 (serine/threonine-protein kinase PAK2) is a serine/threonine kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis, or proliferation. It acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformation change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: gamma pak; Gamma-PAK; OPHN3; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; PAK alpha; PAK beta; PAK gamma; PAK-2; PAK3; PAK65; S6/H4 kinase; Serine/threonine-protein kinase PAK 2
基因别名: 5330420P17Rik; A130002K10Rik; AI836325; D16Ertd269e; gamma-PAK; mKIAA4182; PAK-2; PAK2; PAK65; PAKgamma
UniProt ID: (Human) Q13177, (Mouse) Q8CIN4, (Rat) Q64303
Entrez Gene ID: (Human) 5062, (Mouse) 224105, (Rat) 29432