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Rockland
PALB2 Polyclonal Antibody
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FIGURE: 1 / 1
PALB2 Antibody (600-401-DJ6) in WB
Western Blot of PALB2 antibody. Lane 1: SK-N-SH cell lysate with PALB2 antibody at 1 µg/mL. Lane 2: SK-N-SH cell lysate with PALB2 antibody at 2 µg/mL. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 131 kDa, 150 kDa for PALB2. Other band(s): PALB2 splice variants and isoforms.
Product Details
600-401-DJ6
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-PALB2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the C-terminus of human PALB2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ21816; Partner and localizer of BRCA2
Gene Aliases: BC066140; FANCN; PALB2; PNCA3; RGD1304759
UniProt ID: (Human) Q86YC2, (Mouse) Q3U0P1
Entrez Gene ID: (Human) 79728, (Rat) 293452, (Mouse) 233826
double-strand break repair via homologous recombination
somitogenesis
inner cell mass cell proliferation
mesoderm development
biological_process
organ morphogenesis
post-anal tail morphogenesis
negative regulation of apoptotic process
in utero embryonic development
DNA repair
DNA recombination
cellular response to DNA damage stimulus
chromosome breakage
multicellular organism growth
embryonic organ development
DNA synthesis involved in DNA repair
strand displacement
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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