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Rockland
PAN-SHANK Monoclonal Antibody (N23b/49)
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PAN-SHANK Antibody (200-301-G42) in WB
Western Blot of mouse anti-SHANK antibody. Lane 1: Rat Brain Membrane lysate. Primary antibody: SHANK antibody at 1:1,000 for overnight at 4°C. Secondary antibody: Goat anti-mouse IgG HRP secondary antibody at 1:10,000 for 45 min at RT. Block: 5% Blotto overnight 4°C. Predicted/Observed size: 158.6 kDa/160 kDa. Other band(s): none.
产品信息
200-301-G42
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N23b/49
抗原
SHANK Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to an internal region of rat Shank2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.2, with 50% glycerol
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CortBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; proline rich synapse associated protein 1; proline rich synapse associated protein 2; proline-rich synapse associated protein 1; Proline-rich synapse-associated protein 1; Proline-rich synapse-associated protein 2; ProSAP1; ProSAP2; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3 and multiple ankyrin repeat domains protein 2; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; SH3/ankyrin domain gene 1; SH3/ankyrin domain gene 2; SH3/ankyrin domain gene 3; shank postsynaptic density protein; Shank postsynaptic density protein 3a; Shank1; Shank2; Shank3; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; shank3e splice variant III; shank3e splice variant IV; Somatostatin receptor-interacting protein; SPANK-1; SPANK-2; SPANK-3; SSTR-interacting protein; Synamon
基因别名: AI841104; AUTS17; CORTBP1; CTTNBP1; DEL22q13.3; KIAA1022; Kiaa1650; mKIAA1022; PROSAP1; PROSAP2; PSAP2; SCZD15; SHANK; SHANK1; Shank1a; SHANK2; Shank3; Shank3b; SHANK3c-3; SHANK3c-4; SPANK-1; SPANK-2; SPANK-3; Spank1; SSTRIP; synamon
UniProt ID: (Human) Q9Y566, (Human) Q9UPX8, (Rat) Q9WV48, (Mouse) D3YZU1, (Mouse) Q80Z38, (Rat) Q9QX74, (Mouse) Q4ACU6, (Rat) Q9JLU4
Entrez Gene ID: (Human) 50944, (Human) 22941, (Human) 85358, (Rat) 78957, (Mouse) 243961, (Mouse) 210274, (Rat) 171093, (Mouse) 58234, (Rat) 59312
protein binding
protein C-terminus binding
SH3 domain binding
GKAP/Homer scaffold activity
somatostatin receptor binding
protein complex binding
ionotropic glutamate receptor binding
identical protein binding
ankyrin repeat binding
scaffold protein binding
actin binding
zinc ion binding
receptor signaling complex scaffold activity
protein self-association
protein complex assembly
cytoskeletal anchoring at plasma membrane
long-term memory
associative learning
adult behavior
negative regulation of actin filament bundle assembly
social behavior
protein localization to synapse
olfactory behavior
habituation
neuromuscular process controlling balance
determination of affect
righting reflex
synapse maturation
dendritic spine morphogenesis
positive regulation of dendritic spine development
vocalization behavior
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
MAPK cascade
embryonic epithelial tube formation
synapse assembly
learning
memory
striatal medium spiny neuron differentiation
locomotory exploration behavior
vocal learning
negative regulation of cell volume
positive regulation of long-term neuronal synaptic plasticity
brain morphogenesis
protein oligomerization
positive regulation of synapse structural plasticity
positive regulation of synaptic transmission, glutamatergic
regulation of dendritic spine morphogenesis
postsynaptic density assembly
AMPA glutamate receptor clustering
NMDA glutamate receptor clustering
guanylate kinase-associated protein clustering
regulation of long-term synaptic potentiation
positive regulation of long-term synaptic potentiation
positive regulation of glutamate receptor signaling pathway
regulation of long term synaptic depression
regulation of grooming behavior
regulation of behavioral fear response
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
exploration behavior
long-term synaptic potentiation
long term synaptic depression
nervous system development
cell differentiation
brain development
response to nutrient
