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Invitrogen

PAR2 Recombinant Rabbit Monoclonal Antibody (16C12)

查看其他23个PAR2抗体

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产品信息

MA573076

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:500
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

流式细胞分析 (Flow)

1:50-1:100
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

16C12

抗原

KLH conjugated synthetic peptide derived from human PAR2.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.125 mg/mL

规格

12.5 µg

纯化类型

Protein A

保存液

TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: coagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; G-protein-coulped receptor; PAR-2; PAR-2; protease-activated receptor 2; Protease-activated receptor-2; Proteinase-activated receptor 2; proteinase-activated receptor-2; Proteinase-activated receptor-2 G protein-coupled receptor 11; Proteinase-activated receptor-2, G protein-coupled receptor 11; Thrombin receptor-like 1

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基因别名: F2RL1; Gpcr11; GPR11; PAR-2; PAR2

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UniProt ID: (Human) P55085, (Mouse) P55086, (Rat) Q63645

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Entrez Gene ID: (Human) 2150, (Mouse) 14063, (Rat) 116677

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功能
proteinase activated receptor activity G-protein alpha-subunit binding protease binding G-protein coupled receptor activity receptor binding protein binding thrombin receptor activity G-protein beta-subunit binding signaling receptor activity signal transducer activity heterotrimeric G-protein binding G-protein coupled receptor
参与通路
T cell activation involved in immune response immune system process positive regulation of leukocyte chemotaxis positive regulation of cytokine production involved in immune response positive regulation of glomerular filtration inflammatory response signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration blood coagulation negative regulation of tumor necrosis factor-mediated signaling pathway regulation of blood coagulation positive regulation of cell migration positive regulation of actin filament depolymerization positive regulation of pseudopodium assembly negative regulation of chemokine production positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of superoxide anion generation positive regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of Rho protein signal transduction neutrophil activation vasodilation regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of eosinophil degranulation positive regulation of GTPase activity innate immune response cell-cell junction maintenance positive regulation of transcription from RNA polymerase II promoter regulation of JNK cascade negative regulation of JNK cascade positive regulation of JNK cascade negative regulation of insulin secretion leukocyte migration positive regulation of chemotaxis positive regulation of positive chemotaxis defense response to virus positive regulation of protein kinase B signaling positive regulation of phagocytosis, engulfment establishment of endothelial barrier regulation of biological quality positive regulation of ERK1 and ERK2 cascade thrombin receptor signaling pathway leukocyte proliferation positive regulation of neutrophil mediated killing of gram-negative bacterium mature conventional dendritic cell differentiation positive regulation of renin secretion into blood stream regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of cytokine secretion involved in immune response positive regulation of phosphatidylinositol 3-kinase signaling chemokine (C-C motif) ligand 2 secretion positive regulation of vasodilation interleukin-1 beta secretion interleukin-10 secretion interferon-gamma secretion chemokine secretion negative regulation of chemokine secretion positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion protein secretion
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