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Alomone Labs, LTD
PAR4 (F2RL3) (extracellular) Polyclonal Antibody
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PAR4 (F2RL3) (extracellular) Antibody (APR-034-200UL) in ICC/IF
Expression of PAR-4 in a human breast adenocarcinoma cell line - Cell surface detection of PAR-4 in a human breast adenocarcinoma cell line. A. Live intact human MCF-7 cells were stained with Anti-PAR4 (F2RL3) (extracellular) Antibody (#APR-034), (1:50), followed by goat Anti-rabbit-AlexaFluor-488 secondary Antibody (green). B. Live view of the cells. C. Nuclei were visualized with the cell-permeable dye Ho... View More
产品信息
APR-034-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)HLRGQRWPFGEAA(S)R, corresponding to amino acid residues 136-150 of human PAR-4, 1stextracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: coagulation factor II (thrombin) receptor-like 3; Coagulation factor II receptor-like 3; PAR-4; protease-activated receptor 4; protease-activated receptor-4; Proteinase-activated receptor 4; Thrombin receptor-like 3
基因别名: F2RL3; PAR4
UniProt ID: (Human) Q96RI0, (Rat) Q920E0, (Mouse) O88634
Entrez Gene ID: (Human) 9002, (Rat) 116498, (Mouse) 14065
signal transduction
phospholipase C-activating G-protein coupled receptor signaling pathway
blood coagulation
response to wounding
platelet activation
positive regulation of release of sequestered calcium ion into cytosol
platelet dense granule organization
thrombin receptor signaling pathway
G-protein coupled receptor signaling pathway
hemostasis
