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Invitrogen
PARN Polyclonal Antibody
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PARN Antibody (PA5-79783) in ICC/IF
Immunocytochemistry analysis of PARN using anti-PARN antibody (Product # PA5-79783) . PARN was detected in a section of A549 cell. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 2μg/mL rabbit anti-PARN antibody (Product # PA5-79783) overnight at 4°C. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visual... View More
产品信息
PA5-79783
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived human PARN recombinant protein (Position: M1-Y301).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human placenta tissue, human COLO-320 whole cell, human HepG2 whole cell, human PANC-1 whole cell, human SGC-7901 whole cell, human MDA-MB-231 whole cell, rat kidney tissue, mouse heart tissue, mouse kidney tissue. IHC: human mammary cancer tissue, mouse small intestine tissue, rat small intestine tissue. ICC/IF: A549 cell. Flow: A431 cell.
靶标信息
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deadenylating nuclease; Deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); Poly(A)-specific ribonuclease PARN; Polyadenylate-specific ribonuclease
基因别名: 1200003I18Rik; DAN; DKCB6; PARN; PFBMFT4; RGD1565449
UniProt ID: (Human) O95453, (Mouse) Q8VDG3
Entrez Gene ID: (Human) 5073, (Mouse) 74108, (Rat) 360464
