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Invitrogen
PARVA Polyclonal Antibody
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产品信息
PA1-25074
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the N-terminal region of mouse actopaxin (amino acids 35-53).
偶联物
形式
Liquid
浓度
8.3 mg/mL
纯化类型
IgG fraction
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: ECV304.
PA1-25074 is expected to cross react with human (94% conserved) and rat (100% conserved) due to sequence homology.
The PA1-25074 immunogen is a synthetic peptide gtlarrkkakevsefqeeg conjugated to KLH, corresponding to amino acids 35-53 of Mouse Parvin alpha. The sequence is identical in human actopaxin and has considerable homology (70%) with beta parvin/affixin, but no homology with gamma parvin.
靶标信息
The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Actopaxin; Alpha-parvin; Calponin-like integrin-linked kinase-binding protein; CH-ILKBP; FLJ10793; FLJ12254; Matrix-remodeling-associated protein 2; parvin, alpha
基因别名: 2010012A22Rik; 5430400F08Rik; Actp; AI225929; AU042898; CH-ILKBP; MNCb-0301; MXRA2; PARVA; Parvin
UniProt ID: (Human) Q9NVD7, (Mouse) Q9EPC1
Entrez Gene ID: (Human) 55742, (Mouse) 57342
sprouting angiogenesis
outflow tract septum morphogenesis
establishment or maintenance of cell polarity
regulation of cell shape
actin cytoskeleton reorganization
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
cilium morphogenesis
actin-mediated cell contraction
smooth muscle cell chemotaxis
angiogenesis
chemotaxis
cell adhesion
cell projection organization
actin cytoskeleton organization
protein heterooligomerization
