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PAX2 Monoclonal Antibody (3C7)

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抗体检测数据 (3)

PAX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PAX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PAX2 Antibody (H00005076-M01) in IHC (P)

Immunoperoxidase of monoclonal antibody to PAX2 on formalin-fixed paraffin-embedded human adrenal gland. Antibody concentration is 0.5 µg/mL.

PAX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PAX2 Antibody in Western Blot (WB)

PAX2 Antibody in ELISA (ELISA)

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PAX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunoperoxidase of monoclonal antibody to PAX2 on formalin-fixed paraffin-embedded human adrenal gland. Antibody concentration is 0.5 µg/mL.

PAX2 Antibody in Western Blot (WB) — Western Blot analysis of PAX2 expression in transfected 293T cell line by PAX2 monoclonal antibody (M01), clone 3C7.

Lane 1: PAX2 transfected lysate(47.41 KDa).
Lane 2: Non-transfected lysate.

PAX2 Antibody in ELISA (ELISA) — Detection limit for recombinant GST tagged PAX2 is 0.03 ng/mL as a capture antibody.

产品信息

H00005076-M01

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

免疫组化（石蜡） (IHC (P))

0.5 µg/mL

-

酶联免疫吸附实验 (ELISA)

0.03 ng/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

3C7

抗原

PAX2 (NP_000269, 194 a.a. approximately 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: PRSNGEKRKR DEDVSEGSVP NGDSQSGVDS LRKHLRADTF TQQQLEALDR VFERPSYPDV FQASEHIKSE QGNEYSLPAL TPGLDEVKSS LSASTNPELG SNVSGTQTYP

靶标信息

The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: paired box homeotic gene 2; Paired box protein Pax-2

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基因别名: FSGS7; PAPRS; PAX2

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UniProt ID: (Human) Q02962

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Entrez Gene ID: (Human) 5076

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core promoter proximal region sequence-specific DNA binding DNA binding protein binding transcription factor binding superoxide-generating NADPH oxidase activity transcription regulatory region DNA binding

参与通路

urogenital system development branching involved in ureteric bud morphogenesis cell fate determination mesonephros development neural tube closure optic cup morphogenesis involved in camera-type eye development mesenchymal to epithelial transition involved in metanephros morphogenesis retinal pigment epithelium development transcription, DNA-templated transcription from RNA polymerase II promoter axonogenesis mesodermal cell fate specification aging visual perception glial cell differentiation optic nerve development optic nerve morphogenesis optic nerve structural organization vestibulocochlear nerve formation response to nutrient levels regulation of metanephros size ureter maturation pronephric field specification inner ear morphogenesis camera-type eye development negative regulation of apoptotic process negative regulation of programmed cell death negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase B signaling negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of cytolysis positive regulation of transcription from RNA polymerase II promoter pronephros development brain morphogenesis stem cell differentiation positive regulation of epithelial cell proliferation oxidation-reduction process mesenchymal to epithelial transition optic chiasma development cellular response to hydrogen peroxide cellular response to retinoic acid cellular response to glucose stimulus cellular response to epidermal growth factor stimulus metanephric mesenchyme development positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric mesenchymal cell differentiation nephric duct formation ureter development metanephric collecting duct development metanephric epithelium development metanephric distal convoluted tubule development metanephric nephron tubule formation positive regulation of metanephric glomerulus development negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation reactive oxygen species metabolic process cochlea development cochlea morphogenesis positive regulation of branching involved in ureteric bud morphogenesis negative regulation of mesenchymal cell apoptotic process involved in metanephros development negative regulation of apoptotic process involved in metanephric collecting duct development negative regulation of apoptotic process involved in metanephric nephron tubule development negative regulation of reactive oxygen species metabolic process positive regulation of metanephric DCT cell differentiation positive regulation of optic nerve formation