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Bethyl Laboratories
PBRM1 Recombinant Rabbit Monoclonal Antibody (BL-39-2C3)
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产品信息
A700-019CF
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BL-39-2C3
抗原
Recombinant protein representing residues 1-293 of Human Polybromo 1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
BBS, pH 8.2
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product is tested in SW-Size.
靶标信息
The PBRM1 gene encodes a subunit of the PBAF (Polybromo-associated BAF) chromatin remodeling complex, playing a crucial role in the regulation of chromatin structure and transcription. PBRM1, also known as BAF180, contains bromodomains that recognize acetylated lysine residues on histone tails, facilitating chromatin remodeling necessary for effective transcriptional regulation. This gene is frequently mutated in renal cell carcinoma, particularly clear cell renal cell carcinoma (ccRCC), where such mutations are implicated in the pathogenesis of the disease. PBRM1 acts as a tumor suppressor, and its loss of function can lead to deregulation of gene expression, contributing to oncogenic processes. It is involved in pathways that govern cell cycle regulation and DNA damage response, reflecting its importance in maintaining genomic stability. Ongoing research focuses on understanding PBRM1's interactions within chromatin remodeling complexes and its potential as a therapeutic target in cancer treatment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2310032M22Rik; BAF180; BRG1-associated factor 180; hPB1; Polybromo-1D; Protein polybromo-1
基因别名: 2610016F04Rik; AI507524; BAF180; PB1; PBRM1
UniProt ID: (Human) Q86U86
Entrez Gene ID: (Human) 55193, (Mouse) 66923
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
mitotic nuclear division
negative regulation of cell proliferation
covalent chromatin modification
placenta development
blood vessel remodeling
heart morphogenesis
epicardium-derived cardiac endothelial cell differentiation
heart development
chromatin modification
positive regulation of transcription, DNA-templated
cardiac vascular smooth muscle cell development
vasculogenesis involved in coronary vascular morphogenesis
