Search
Invitrogen
PCAF Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-75181
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 786-832 of Human PCAF.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CREBBP-associated factor; histone acetylase PCAF; histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; lysine acetyltransferase 2B; P/ PCAF; p300/CBP-associated factor; spermidine acetyltransferase KAT2B; unnamed protein product
基因别名: A930006P13Rik; AABR07066180.1; CAF; P/CAF; PCAF
UniProt ID: (Human) Q92831, (Mouse) Q9JHD1
Entrez Gene ID: (Human) 8850, (Mouse) 18519, (Rat) 301164
RNA polymerase II regulatory region sequence-specific DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
diamine N-acetyltransferase activity
histone acetyltransferase activity
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
enzyme activator activity
H3 histone acetyltransferase activity
acetyltransferase activity
transferase activity, transferring acyl groups other than amino-acyl groups
protein kinase binding
histone acetyltransferase binding
histone deacetylase binding
histone acetyltransferase activity (H3-K9 specific)
peptide-lysine-N-acetyltransferase activity
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter by glucose
regulation of DNA repair
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein acetylation
ubiquitin-dependent protein catabolic process
fatty acid biosynthetic process
heart development
memory
negative regulation of cell proliferation
regulation of gene expression
positive regulation of neuron projection development
N-terminal peptidyl-lysine acetylation
internal peptidyl-lysine acetylation
cellular response to insulin stimulus
cellular response to oxidative stress
vasodilation
regulation of RNA splicing
negative regulation of fatty acid biosynthetic process
positive regulation of gluconeogenesis
positive regulation of fatty acid biosynthetic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of centriole replication
attachment of mitotic spindle microtubules to kinetochore
regulation of cell cycle
limb development
cellular response to parathyroid hormone stimulus
regulation of tubulin deacetylation
negative regulation of ferroptosis
positive regulation of attachment of mitotic spindle microtubules to kinetochore
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of rRNA processing
positive regulation of gene expression, epigenetic
regulation of embryonic development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
