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Abnova
PCAF Monoclonal Antibody (1H2)
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PCAF Antibody (H00008850-M02) in WB
Western blot analysis of PCAF over-expressed 293 cell line, cotransfected with PCAF Validated Chimera RNAi (Cat # H00008850-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with PCAF monoclonal antibody (M02), clone 1H2 (Cat # H00008850-M02). GAPDH ( 36.1 kDa ) used as specificity and loading control.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00008850-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1H2
抗原
PCAF (AAH60823, 353 a.a. approximately 452 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
See Label
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: LEEEVYSQNS PIWDQDFLSA SSRTSQLGIQ TVINPPPVAG TISYNSTSSS LEQPNAGSSS PACKASSGLE ANPGEKRKMT DSHVLEEAKK PRVMGDIPME
靶标信息
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CREBBP-associated factor; histone acetylase PCAF; histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; P/ PCAF; p300/CBP-associated factor; spermidine acetyltransferase KAT2B
基因别名: CAF; P/CAF; PCAF
UniProt ID: (Human) Q92831
Entrez Gene ID: (Human) 8850
RNA polymerase II regulatory region sequence-specific DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
diamine N-acetyltransferase activity
histone acetyltransferase activity
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
enzyme activator activity
H3 histone acetyltransferase activity
acetyltransferase activity
transferase activity, transferring acyl groups other than amino-acyl groups
protein kinase binding
histone acetyltransferase binding
histone deacetylase binding
histone acetyltransferase activity (H3-K9 specific)
peptide-lysine-N-acetyltransferase activity
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter by glucose
regulation of DNA repair
chromatin remodeling
regulation of transcription, DNA-templated
protein acetylation
heart development
memory
negative regulation of cell proliferation
regulation of gene expression
positive regulation of neuron projection development
internal peptidyl-lysine acetylation
cellular response to insulin stimulus
cellular response to oxidative stress
vasodilation
regulation of RNA splicing
positive regulation of fatty acid biosynthetic process
positive regulation of gene expression, epigenetic
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
negative regulation of centriole replication
regulation of cell cycle
limb development
cellular response to parathyroid hormone stimulus
negative regulation of ferroptosis
positive regulation of attachment of mitotic spindle microtubules to kinetochore
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of rRNA processing
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