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Invitrogen
PCAF Recombinant Rabbit Monoclonal Antibody (23GB910)
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PCAF Antibody (MA5-54026) in ICC/IF
Immunocytochemistry analysis of PCAF in HT-1080 cells. Nuclei were stained blue with DAPI; PCAF recombinant monoclonal antibody (Product # MA5-54026) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
产品信息
MA5-54026
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB910
抗原
A synthetic peptide of human PCAF (154-190AA).
偶联物
形式
Liquid
浓度
0.22 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CREBBP-associated factor; Histone acetylase PCAF; Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; Lysine acetyltransferase 2B; P/ PCAF; P/CAF; P300/CBP-associated factor; Spermidine acetyltransferase KAT2B
基因别名: CAF; KAT2B; P/CAF; PCAF
UniProt ID: (Human) Q92831
Entrez Gene ID: (Human) 8850
RNA polymerase II regulatory region sequence-specific DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
histone acetyltransferase activity
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
transcription factor binding
acetyltransferase activity
protein kinase binding
protein complex binding
histone acetyltransferase binding
histone deacetylase binding
chromatin remodeling
transcription initiation from RNA polymerase II promoter
protein acetylation
cell cycle arrest
Notch signaling pathway
memory
negative regulation of cell proliferation
regulation of protein ADP-ribosylation
positive regulation of neuron projection development
viral process
N-terminal peptidyl-lysine acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
cellular response to insulin stimulus
cellular response to oxidative stress
positive regulation of chromatin binding
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
histone H3 acetylation
histone H3-K9 acetylation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of gene expression, epigenetic
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
cellular response to parathyroid hormone stimulus
positive regulation of histone H3-K14 acetylation
positive regulation of histone H3-K9 acetylation
