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Invitrogen
PCBP4 Recombinant Mouse Monoclonal Antibody (K1E075_14F9)
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PCBP4 Antibody (MA564494) in WB
Western blot analysis of PCBP4 in SK-MEL-28 lysate (15 μg). Samples were incubated with PCBP4 recombinant monoclonal (Product # MA564494) using a dilution of 1 µg/mL followed by peroxidase conjugated goat anti-mouse IgG. Sample was run on 6-18% SDS-PAGE under reducing conditions and blotted onto nitrocellulose membrane. PCBP4 band was visualized using ECL Western Blotting Substrate.
产品信息
MA564494
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K1E075_14F9
抗原
Recombinant human PCBP4 (aa 11-290).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.09% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EPELSITLTL RMLMHGKEVG SIIGKKGETV KRIREQSSAR ITISEGSCPE RITTITGSTA AVFHAVSMIA FKLDEDLCAA PANGGNVSRP PVTLRLVIPA SQCGSLIGKA GTKIKEIRET TGAQVQVAGD LLPNSTERAV TVSGVPDAII LCVRQICAVI LESPPKGATI PYHPSLSLGT VLLSANQGFS VQGQYGAVTP AEVTKLQQLS SHAVPFATPS VVPGLDPGTQ TSSQEFLVPN DLIGCVIGRQ GSKISEIRQM SGAHIKIGNQ AEGAGERHVT
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 32%, Pig - 99%, Cynomolgus monkey - 100%.
靶标信息
MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha CP-4; Alpha-CP4; alphaCP-4 protein; LYST-interacting protein; Poly(rC)-binding protein 4; RNA binding protein MCG10
基因别名: CBP; LIP4; MCG10; PCBP4
UniProt ID: (Human) P57723
Entrez Gene ID: (Human) 57060
