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Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAAQRNRSKE SKDCSGLVLL CLFFGIPWEA GARQISYSIP EELEKGSFVG NISKDLGLAP RELAERGVRI VSRGRTQLFS LNPRSGSLIT AGRIDREELC AQSARCVVSF NILVEDRVKL FGIEIEVTDI NDNAPKFQAE NLDVKINENV AAGMRFPLPE AIDPDVGVNS LQSYQLSPNK HFSLRVQSRA NGVKYPELVL EHSLDREEEA IHHLVLTASD GGDPLRSGTV LVSVTVFDAN DNAPVFTLPE YRVSVPENLP VGTQLLTVTA TDRDEGANGE VTYSFRKLPD TQLLKFQLNK YTGEIKISEN LDYEETGFYE IEIQAEDGGA YLATAKVLIT VEDVNDNSPE LTITSLFSPV TEDSPLGTVV ALLNVHDLDS EQNGQVTCSI LAYLPFKLEK SIDSYYRLVI HRALDREQVS SYNITVTATD GGSPPLSTEA HFMLQVADIN DNPPTFSQVS YFTYIPENNA RGASIFSVTA LDPDSKENAQ IIYSLAEDTI QGVPLSSYIS INSDTGVLYA LRSFDYEQFH ELQMQVTASD SGDPPLSSNV SLSLFVLDQN DNAPEILYPA LPTDGSTGVE LAPRSAEPGY LVTKVVAVDR DSGQNAWLSY RLLKASEPGL FAVGEHTGEV RTARALLDRD ALKQSLVVAV QDHGQPPLSA TVTLTVAVAD SIPQVLADLG SFESPANSET SDLTLYLVVA VAAVSCVFLA FVIVLLAHRL RRWHKSRLLQ ASGGGLTGVS GSHFVGVDGV RAFLQTYSHE VSLTADSRKS HLIFPQPNYA DTLISQESCE KNDPLSLLDD SKFPIEDTPL VPVSFIFIFT FVKKKKIGFY FEVCGMMVES VNAKTLMSRI
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: PCDH-gamma-A10; Protocadherin gamma-A10
基因别名: PCDH-GAMMA-A10; PCDHGA10
UniProt ID: (Human) Q9Y5H3
Entrez Gene ID: (Human) 56106