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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: YKWKQSRDLYR APVSSLYRTP GPSLHADAVR GGLMSPHLYH QVYLTTDSRR SDPLLKKPGA ASPLASRQNT LRSCDPVFYR QVLGAES
Highest antigen sequence identity to the following orthologs - mouse 98%, rat 95%.
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cadherin like 2; PC 43; PC-43; PCDH 2; PCDH gamma C3; PCDH-gamma-C3; Pcdhgb6; PCDHGC 3; Protocadherin gamma-C3; Protocadherin-2; Protocadherin-43; Protocadherin2; Protocadherin43
基因别名: PCDH2; PCDHGC3
Entrez Gene ID: (Human) 5098