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Invitrogen
PCGF6 Polyclonal Antibody
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PCGF6 Antibody (PA5-49438) in WB
Western blot analysis of PCGF6 in rat testis lysates. Samples were incubated with PCGF6 polyclonal antibody (Product # PA5-49438) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Predicted band size: 39 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-49438
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 215-249 amino acids from the Central region of human PCGF6.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation. PCGF6 (polycomb group ring finger 6), also known as MBLR or RNF134, is a 350 amino acid nuclear protein that is ubiquitously expressed and contains one RING-type zinc finger. PCGF6 acts as a transcriptional repressor and regulates the level of histone H3K4Me3 by activating SmcY histone demethylase. PCGF6 exists as two alternatively spliced isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mel18 and Bmi1-like RING finger; Polycomb group RING finger protein 6; RING finger protein 134
基因别名: MBLR; PCGF6; RNF134
UniProt ID: (Rat) Q5XI70
Entrez Gene ID: (Rat) 309457
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
molecular_function
DNA binding
transcription factor activity, sequence-specific DNA binding
zinc ion binding
histone modifying enzyme
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