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Invitrogen
PD-L1/4-1BB/CD3/EGFRvIII (Umizortamig Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA562520
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ Ig Mix
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
PD-L1 (B7-H1) is a member of the B7 family that binds to PD-1 on T cells, negatively regulating T cell receptor (TCR) signaling. Engagement of PD-1 by PD-L1 reduces T cell proliferation and cytokine production, thereby dampening immune responses. PD-L1 is widely expressed on many human and murine tumors and can be further upregulated by IFN-gamma, contributing to tumor immune evasion.
CD137 (4-1BB, TNFRSF9) is an inducible costimulatory receptor primarily expressed on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitors. CD137 signaling promotes survival and clonal expansion of activated and CD8+ memory T cells, and influences cytokine production and monocyte survival. It can also suppress myelopoiesis and dendritic cell development. Soluble CD137 forms may help regulate immune responses.
CD3 is a multi-subunit complex (gamma, delta, epsilon, zeta) essential for TCR assembly and surface expression. Expressed on thymocytes and mature T cells, CD3 transduces antigen-recognition signals through tyrosine-based motifs in its cytoplasmic tails. TCR engagement activates intracellular pathways that drive T cell activation, proliferation, survival, or growth arrest. Defects in CD3 lead to immunodeficiency.
EGFRvIII is a tumor-specific mutant form of the epidermal growth factor receptor (EGFR) that is constitutively active due to a deletion in its extracellular domain. Like EGFR, it activates downstream signaling pathways including RAS-RAF-MEK-ERK, PI3K-AKT, PLCg-PKC, STAT, and NF-kB. These pathways promote cell proliferation, survival, and tumor progression. EGFRvIII is commonly found in glioblastoma and represents a target for cancer therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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