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Invitrogen
PD-L1/4-1BBL Humanized Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-60147
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ VHH
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Inbrx-105.
靶标信息
PD-L1 (Programmed Death-Ligand 1) is a transmembrane protein encoded by the CD274 gene located on chromosome 9p24.1. It is expressed on various cell types, including tumor cells, where it plays a critical role in immune evasion by binding to its receptor PD-1 on T cells, thus inhibiting T cell function and allowing tumor cells to escape immune surveillance. PD-L1 has also been implicated in promoting tumor growth, progression, and radioresistance. On the other hand, 4-1BBL (4-1BB ligand) is a member of the tumor necrosis factor (TNF) superfamily expressed on antigen-presenting cells (APCs) such as dendritic cells, B cells, and macrophages. It is encoded by the TNFSF9 gene on chromosome 19p13.3. 4-1BBL binds to its receptor 4-1BB (CD137) on T cells, providing a co-stimulatory signal that enhances T cell proliferation and survival, as well as cytokine production. The interaction between 4-1BBL and 4-1BB is crucial in the regulation of immune responses, particularly in cancer immunotherapy, where it is leveraged to boost anti-tumor immunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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