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Invitrogen
PD-L1/CD47 Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-60155
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Hx009.
靶标信息
Programmed Cell Death Ligand 1 (PD-L1) and Cluster of Differentiation 47 (CD47) are two significant molecules involved in the immune evasion mechanisms of cancer cells. PD-L1, encoded by the CD274 gene, is a transmembrane protein that interacts with the PD-1 receptor on T-cells, leading to the inhibition of T-cell activation and proliferation, thus allowing cancer cells to evade immune detection. This pathway is targeted by several immunotherapeutic drugs, including pembrolizumab and nivolumab, which have shown effectiveness in treating various cancers. On the other hand, CD47, a transmembrane protein encoded by the CD47 gene, sends a "don't eat me" signal by binding to the Signal-Regulatory Protein Alpha (SIRP alpha) on myeloid cells, thereby inhibiting phagocytosis of cancer cells by macrophages. Overexpression of CD47 is observed in many tumors and is associated with poor prognosis. Therapeutic strategies targeting the CD47-SIRP alpha axis are being developed to enhance the phagocytosis of cancer cells and improve anti-tumor immunity. Both PD-L1 and CD47 play crucial roles in the tumor microenvironment by helping cancer cells evade immune destruction, and targeting these pathways has become a promising approach in cancer immunotherapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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