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Invitrogen
PD-L1/TGF beta Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-60149
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Tqb2858.
靶标信息
Programmed Cell Death Ligand 1 (PD-L1), encoded by the CD274 gene, is a trans-membrane protein that serves as a co-inhibitory factor in the immune response. It is widely expressed on the surface of various tumor cells, where it binds to the PD-1 receptor on T cells to suppress the immune response, thus facilitating tumor immune escape. The TGF-beta (transforming growth factor beta) gene family, on the other hand, includes multifunctional cytokines that play crucial roles in regulating cellular processes, including cell growth, differentiation, apoptosis, and homeostasis. Both PD-L1 and TGF-beta are pivotal in immune regulation and tumor progression; their interaction often contributes to the immunosuppressive tumor microenvironment. While PD-L1 directly inhibits T-cell function, TGF-beta signaling can modulate immune responses and enhance PD-L1 expression, creating a synergistic effect that leads to tumor immune evasion and progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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