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Invitrogen
PD-L1/TGF beta (Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA5-60149
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Tqb2858.
靶标信息
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
The TGF-beta (transforming growth factor beta) gene encodes a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGF-beta acts as a cellular switch to regulate immune responses, cell growth, apoptosis, and cellular homeostasis. The human TGF-beta family comprises three isoforms: TGF-beta 1, TGF-beta 2, and TGF-beta 3, encoded by the genes TGFB1, TGFB2, and TGFB3 located on chromosomes 19q13, 1q41, and 14q24 respectively. These genes produce inactive precursor proteins, which are further processed into active forms. The mature TGF-beta protein is a dimer formed by two identical peptide chains linked by disulfide bonds. It signals through serine/threonine kinase receptors and downstream SMAD transcription factors, leading to the regulation of target gene expression. TGF-beta is crucial for tissue homeostasis and immune system modulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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