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Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Programmed cell death protein 2; Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8
基因别名: PDCD2; RP8; ZMYND7
UniProt ID: (Human) Q58HN0
Entrez Gene ID: (Human) 5134