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Invitrogen
PDCD6 Polyclonal Antibody
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Product Details
PA5-119356
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Programmed Cell Death Protein 6. The antigen corresponds to amino acid range 32-191 of the target protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
An increased intracellular Ca2+ concentration induces apoptotic cell death. Transiently elevated Ca2+ concentrations are required for glucocorticoid-mediated and T cell receptor-mediated pathways, leading to T cell apoptosis. ALG-2 (for apoptosis-linked gene 2) is a Ca2+ -binding protein that participates in regulatory events occuring late in the apoptotic program and where several death signals converge. ALG-2 is a protein expressed in normal brain, and to a greater extent in ischemic brain. The ALG-2 protein contains five EF-hand-like motifs and shares homology with members of the penta EF-hand family, which includes Calpain small subunits sorcin and Grancalcin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALG-2; Apoptosis-linked gene 2 protein homolog; probable calcium-binding protein ALG-2; Programmed cell death protein 6; unnamed protein product
Gene Aliases: ALG-2; ALG2; PDCD6; PEF1B
UniProt ID: (Human) O75340
Entrez Gene ID: (Human) 10016
magnesium ion binding
calcium ion binding
protein binding
protein binding, bridging
identical protein binding
protein homodimerization activity
protein anchor
metal ion binding
protein heterodimerization activity
protein dimerization activity
calcium-dependent protein binding
protein binding, bridging involved in substrate recognition for ubiquitination
angiogenesis
positive regulation of endothelial cell proliferation
intracellular protein transport
ER to Golgi vesicle-mediated transport
apoptotic process
positive regulation of endothelial cell migration
neural crest formation
neural crest cell development
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of TOR signaling
cellular response to heat
vascular endothelial growth factor receptor-2 signaling pathway
positive regulation of apoptotic process
positive regulation of angiogenesis
COPII vesicle coating
response to calcium ion
negative regulation of protein kinase B signaling
apoptotic signaling pathway
positive regulation of protein monoubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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