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Abnova
PDCD6 Monoclonal Antibody (2B4)
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产品信息
H00010016-M01J
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2B4
抗原
PDCD6 (AAH12384.1, 92 a.a. approximately 191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: ITDWQNVFRT YDRDNSGMID KNELKQALSG FGYRLSDQFH DILIRKFDRQ GRGQIAFDDF IQGCIVLQRL TDIFRRYDTD QDGWIQVSYE QYLSMVFSIV
Cell culture grade monoclonal antibodies are obtained by purifying "hybridoma culture medium" which completely eliminates any contamination of mice. They have high affinity, high purity, and no contamination.
靶标信息
An increased intracellular Ca2+ concentration induces apoptotic cell death. Transiently elevated Ca2+ concentrations are required for glucocorticoid-mediated and T cell receptor-mediated pathways, leading to T cell apoptosis. ALG-2 (for apoptosis-linked gene 2) is a Ca2+ -binding protein that participates in regulatory events occuring late in the apoptotic program and where several death signals converge. ALG-2 is a protein expressed in normal brain, and to a greater extent in ischemic brain. The ALG-2 protein contains five EF-hand-like motifs and shares homology with members of the penta EF-hand family, which includes Calpain small subunits sorcin and Grancalcin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALG-2; apoptosis-linked gene 2 protein; Apoptosis-linked gene 2 protein homolog; probable calcium-binding protein ALG-2; Programmed cell death protein 6
基因别名: ALG-2; ALG2; PDCD6; PEF1B
UniProt ID: (Human) O75340
Entrez Gene ID: (Human) 10016
angiogenesis
positive regulation of endothelial cell proliferation
proteolysis
intracellular protein transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of endothelial cell migration
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of TOR signaling
cellular response to heat
vascular endothelial growth factor receptor-2 signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of angiogenesis
response to calcium ion
negative regulation of protein kinase B signaling
apoptotic signaling pathway
