Search
Fabgennix
PDE2A2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PD2A2-201AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A2 protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase; PDE2A; PDE2A1; PDE2A2; PED2A4; phosphodiesterase 2A, cGMP-stimulated; unnamed protein product
基因别名: CGS-PDE; cGSPDE; IDDPADS; Pde2; PDE2A1; Pde2a2; PED2A4
UniProt ID: (Human) O00408, (Mouse) Q922S4, (Rat) Q01062
Entrez Gene ID: (Human) 5138, (Mouse) 207728, (Rat) 81743
magnesium ion binding
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
protein binding
phosphoric diester hydrolase activity
zinc ion binding
cAMP binding
cGMP binding
TPR domain binding
phosphate ion binding
identical protein binding
protein homodimerization activity
3',5'-cyclic-GMP phosphodiesterase activity
GAF domain binding
negative regulation of transcription from RNA polymerase II promoter
heart valve development
ventricular septum development
signal transduction
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of gene expression
negative regulation of cGMP-mediated signaling
regulation of mitochondrion organization
monocyte differentiation
aorta development
cellular response to macrophage colony-stimulating factor stimulus
negative regulation of vascular permeability
positive regulation of vascular permeability
cGMP catabolic process
positive regulation of inflammatory response
establishment of endothelial barrier
cellular response to mechanical stimulus
cellular response to cAMP
cellular response to cGMP
cellular response to xenobiotic stimulus
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of cAMP/PKA signal transduction
cellular response to 2,3,7,8-tetrachlorodibenzodioxine
cardiac septum development
cAMP catabolic process
heart development
negative regulation of signal transduction
intracellular signal transduction
coronary vasculature development
cellular response to lipopolysaccharide
negative regulation of oxidative phosphorylation
negative regulation of nitric oxide-cGMP mediated signal transduction
regulation of intracellular signal transduction
response to hydrogen sulfide
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
