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Fabgennix
PDE2A4 Polyclonal Antibody, Biotin
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产品信息
PD2A4-BIOTIN
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide specific only for PDE2A4 protein. Taken within amino acid region 1-50 on human PDE2A4 protein.
偶联物
Biotin
Biotin
Biotin
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; cGSPDE; cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; PDE2A
基因别名: CGS-PDE; cGSPDE; Pde2; PDE2A; Pde2a2
UniProt ID: (Rat) Q01062, (Mouse) Q922S4
Entrez Gene ID: (Rat) 81743, (Mouse) 207728
cyclic-nucleotide phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
protein binding
drug binding
cAMP binding
cGMP binding
TPR domain binding
GAF domain binding
protein homodimerization activity
metal ion binding
nucleotide binding
3',5'-cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
phosphodiesterase
negative regulation of transcription from RNA polymerase II promoter
cAMP catabolic process
protein targeting to mitochondrion
metabolic process
positive regulation of gene expression
cAMP-mediated signaling
cGMP-mediated signaling
monocyte differentiation
negative regulation of cAMP biosynthetic process
regulation of cGMP metabolic process
negative regulation of protein import into nucleus, translocation
cellular response to drug
cellular response to macrophage colony-stimulating factor stimulus
negative regulation of vascular permeability
positive regulation of vascular permeability
cGMP catabolic process
positive regulation of inflammatory response
establishment of endothelial barrier
cellular response to mechanical stimulus
cellular response to cGMP
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
signal transduction
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