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PDE2A4 Polyclonal Antibody, Biotin

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PDE2A4 Polyclonal Antibody, Biotin

产品信息

PD2A4-BIOTIN

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

酶联免疫吸附实验 (ELISA)

1:10,000
-

免疫沉淀 (IP)

1:50-1:250
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide specific only for PDE2A4 protein. Taken within amino acid region 1-50 on human PDE2A4 protein.
3D表位/免疫原

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; CGS-PDE; cGSPDE; cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; PDE2A; PDE2A1; PDE2A2; PED2A4; phosphodiesterase 2A, cGMP-stimulated; unnamed protein product

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基因别名: CGS-PDE; cGSPDE; IDDPADS; Pde2; PDE2A; PDE2A1; Pde2a2; PED2A4

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UniProt ID: (Human) O00408, (Rat) Q01062, (Mouse) Q922S4

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Entrez Gene ID: (Human) 5138, (Rat) 81743, (Mouse) 207728

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功能
nucleotide binding magnesium ion binding 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity protein binding phosphoric diester hydrolase activity zinc ion binding hydrolase activity cAMP binding cGMP binding TPR domain binding phosphate ion binding identical protein binding protein homodimerization activity metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity cyclic-nucleotide phosphodiesterase activity drug binding GAF domain binding phosphodiesterase
参与通路
negative regulation of transcription from RNA polymerase II promoter heart valve development ventricular septum development signal transduction adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of gene expression regulation of cGMP-mediated signaling negative regulation of cGMP-mediated signaling regulation of mitochondrion organization cGMP-mediated signaling monocyte differentiation aorta development cellular response to macrophage colony-stimulating factor stimulus negative regulation of vascular permeability positive regulation of vascular permeability cGMP catabolic process positive regulation of inflammatory response establishment of endothelial barrier cellular response to mechanical stimulus cellular response to cAMP cellular response to cGMP cellular response to xenobiotic stimulus cellular response to transforming growth factor beta stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of cAMP/PKA signal transduction cellular response to 2,3,7,8-tetrachlorodibenzodioxine cAMP catabolic process protein targeting to mitochondrion metabolic process cAMP-mediated signaling negative regulation of cAMP biosynthetic process regulation of cGMP metabolic process negative regulation of protein import into nucleus, translocation cellular response to drug
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