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Fabgennix
PDE3A Polyclonal Antibody, FITC
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Product Details
PD3A-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide selective only for PDE3A variants
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cyclic nucleotide phosphodiesterases (PDEs) comprise a complex group of enzymes, and at least 5 major PDE families or classes with distinctive properties have been identified. Members of the cGMP-inhibited cAMP PDE (cGI-PDE) family, such as PDE3A, are characterized by high affinity for cAMP and cGMP and competitive inhibition of their cAMP hydrolytic activity by cGMP and certain positive inotropic agents (Meacci et al., 1992 [PubMed 1315035]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP phosphodiesterase, myocardial cGMP-inhibited; cGI-PDE; CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited cAMP phosphodiesterase; cGMP-inhibited phosphodiesterase; Cyclic GMP-inhibited phosphodiesterase A; cyclic nucleotide phosphodiesterase; phosphodiesterase 3A, cGMP-inhibited
Gene Aliases: A930022O17Rik; C87899; CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB; PDE3A; RNPDE3A
UniProt ID: (Human) Q14432, (Mouse) Q9Z0X4, (Rat) Q62865
Entrez Gene ID: (Human) 5139, (Mouse) 54611, (Rat) 50678
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
protein binding
phosphoric diester hydrolase activity
hydrolase activity
estrogen receptor activity
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
estrogen binding
cAMP binding
cyclic-nucleotide phosphodiesterase activity
phosphodiesterase
oocyte maturation
lipid metabolic process
signal transduction
G-protein coupled receptor signaling pathway
response to xenobiotic stimulus
cGMP-mediated signaling
intracellular steroid hormone receptor signaling pathway
regulation of meiotic nuclear division
negative regulation of apoptotic process
negative regulation of vascular permeability
positive regulation of vascular permeability
oocyte development
positive regulation of oocyte development
regulation of ribonuclease activity
cellular response to cGMP
cellular response to transforming growth factor beta stimulus
apoptotic signaling pathway
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of cAMP/PKA signal transduction
cAMP catabolic process
cAMP-mediated signaling
response to drug
diterpenoid metabolic process
response to cAMP
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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