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Fabgennix

PDE4D3 Polyclonal Antibody, Biotin

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说明书
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说明书
Certificates
实验方案
问题与答案
技术支持
说明书
Certificates
实验方案
问题与答案
技术支持
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产品信息

PD4D3-BIOTIN

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫组化 (IHC)

1:50-1:250
-

免疫细胞化学 (ICC/IF)

1:50-1:250
-

酶联免疫吸附实验 (ELISA)

1:10,000
-

免疫沉淀 (IP)

1:50-1:250
-

免疫电镜技术 (IM)

1:50-1:200
-
产品规格

种属反应

Chicken, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to unique amino acid sequence on PDE4D3 variant gene.

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

PDE4D3 (Phosphodiesterase 4D, cAMP-specific, isoform 3) is an enzyme encoded by the PDE4D gene, which is located on chromosome 5. PDE4D3 belongs to the PDE4 family, which plays a crucial role in hydrolyzing cyclic AMP (cAMP), thereby regulating intracellular levels of this important signaling molecule. PDE4D3 is integral in modulating cAMP signaling pathways, impacting processes such as cardiac function and inflammation. This isoform of phosphodiesterase has been found to interact within a large protein complex, including Epac1, PKA, and ERK5, which is anchored by mAKAP. Phosphorylation by ERK decreases PDE4D3 activity, leading to local cAMP accumulation and increased activation of cAMP-dependent pathways.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: 3',5'-cyclic AMP phosphodiesterase; alternatively spliced; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE4D1; PDE4D10; PDE4D11; PDE4D2_v1; PDE4D2_v2; PDE4D2_v3; PDE4D3; PDE4D6; PDE4D7; phosphodiesterase 4D, cAMP-specific; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); splice variant PDE4D4; unnamed protein product

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基因别名: 9630011N22Rik; DPDE3; PDE3/IVd

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UniProt ID: (Rat) P14270, (Mouse) Q01063

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Entrez Gene ID: (Chicken) 769469, (Rat) 24627, (Mouse) 238871

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功能
cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity calcium channel regulator activity protein binding phosphoric diester hydrolase activity enzyme binding receptor regulator activity cAMP binding beta-2 adrenergic receptor binding ion channel binding 3',5'-cyclic-GMP phosphodiesterase activity ATPase binding scaffold protein binding heterocyclic compound binding phosphodiesterase
参与通路
ovulation from ovarian follicle positive regulation of protein phosphorylation regulation of heart rate cAMP catabolic process smooth muscle contraction signal transduction memory positive regulation of heart rate regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum positive regulation of smooth muscle cell migration positive regulation of cell-cell adhesion lung development neutrophil chemotaxis positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-5 production multicellular organism growth negative regulation of heart contraction positive regulation of smooth muscle cell proliferation T cell receptor signaling pathway leukocyte migration establishment of endothelial barrier protein-containing complex assembly cellular response to lipopolysaccharide cellular response to cAMP cellular response to follicle-stimulating hormone stimulus cellular response to epinephrine stimulus adrenergic receptor signaling pathway regulation of cardiac muscle cell contraction negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway cAMP/PKA signal transduction regulation of cAMP/PKA signal transduction negative regulation of cAMP/PKA signal transduction regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of relaxation of cardiac muscle regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of G-protein coupled receptor protein signaling pathway
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