Invitrogen

PDGFA Polyclonal Antibody

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说明书
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说明书
实验方案
问题与答案
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说明书
实验方案
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PDGFA Polyclonal Antibody

产品信息

PA5-117291

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

full lengt human PDGFA recombinant protein.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2901921

产品详细信息

Centrifuge briefly prior to opening.

靶标信息

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: PDGF A-chain; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha chain; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A

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基因别名: PDGF-A; PDGF1; PDGFA

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UniProt ID: (Human) P04085

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Entrez Gene ID: (Human) 5154

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功能
Ras guanyl-nucleotide exchange factor activity platelet-derived growth factor receptor binding protein binding collagen binding growth factor activity protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity platelet-derived growth factor binding growth factor
参与通路
MAPK cascade angiogenesis response to hypoxia cell activation hair follicle development positive regulation of mesenchymal cell proliferation platelet degranulation transforming growth factor beta receptor signaling pathway cell-cell signaling positive regulation of cell proliferation response to wounding organ morphogenesis response to inorganic substance negative regulation of phosphatidylinositol biosynthetic process negative regulation of platelet activation regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling regulation of smooth muscle cell migration cell projection assembly actin cytoskeleton organization extracellular matrix organization positive regulation of cell migration positive regulation of protein autophosphorylation response to estradiol response to retinoic acid regulation of actin cytoskeleton organization positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway wound healing response to drug positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of GTPase activity skin development positive regulation of DNA replication phosphatidylinositol phosphorylation platelet-derived growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of fibroblast proliferation lung alveolus development inner ear development regulation of peptidyl-tyrosine phosphorylation negative chemotaxis positive regulation of cell division positive regulation of protein kinase B signaling regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling positive regulation of ERK1 and ERK2 cascade regulation of glomerular mesangial cell proliferation embryonic lung development regulation of DNA biosynthetic process
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