Invitrogen

PDGFRB Polyclonal Antibody

查看其他73个PDGFRB (CD140b)抗体

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说明书
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问题与答案
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说明书
实验方案
问题与答案
技术支持
PDGFRB Polyclonal Antibody

产品信息

PA5-95530

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL
-

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL
-

酶联免疫吸附实验 (ELISA)

0.1-0.5 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived human PDGFRB recombinant protein (Position: E911-L992).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Affinity chromatography

保存液

PBS with 4mg trehalose

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2807332

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human Hela whole cell, human HepG2 whole cell, human SGC-7901 whole cell, human K562 whole cell, rat testis tissue, mouse testis tissue. IHC: human placenta tissue, rat kidney tissue, mouse kidney tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide

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基因别名: AI528809; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT

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UniProt ID: (Human) P09619, (Rat) Q05030, (Mouse) P05622

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Entrez Gene ID: (Human) 5159, (Rat) 24629, (Mouse) 18596

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功能
protein tyrosine kinase activity platelet activating factor receptor activity platelet-derived growth factor-activated receptor activity platelet-derived growth factor beta-receptor activity Ras guanyl-nucleotide exchange factor activity receptor binding platelet-derived growth factor receptor binding protein binding ATP binding protein kinase binding vascular endothelial growth factor binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity platelet-derived growth factor binding protein kinase activity signal transducer activity kinase activity nucleotide binding transmembrane receptor protein tyrosine kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
参与通路
MAPK cascade glycosaminoglycan biosynthetic process signal transduction G-protein coupled receptor signaling pathway positive regulation of cell proliferation response to toxic substance positive regulation of phospholipase C activity regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration cell migration peptidyl-tyrosine phosphorylation positive regulation of cell migration response to estradiol positive regulation of phosphoprotein phosphatase activity response to retinoic acid regulation of actin cytoskeleton organization positive regulation of collagen biosynthetic process response to fluid shear stress cell migration involved in vasculogenesis metanephric mesenchymal cell migration platelet-derived growth factor receptor-beta signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway aorta morphogenesis cellular response to platelet-derived growth factor stimulus positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway wound healing response to hydrogen peroxide negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity response to estrogen positive regulation of mitotic nuclear division phosphatidylinositol metabolic process protein autophosphorylation phosphatidylinositol phosphorylation platelet-derived growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of smooth muscle cell proliferation inner ear development positive regulation of chemotaxis cardiac myofibril assembly response to hyperoxia cell chemotaxis cell migration involved in coronary angiogenesis retina vasculature development in camera-type eye positive regulation of ERK1 and ERK2 cascade smooth muscle cell chemotaxis metanephric mesenchyme development metanephric glomerular mesangial cell proliferation involved in metanephros development metanephric glomerular capillary formation metanephric comma-shaped body morphogenesis metanephric S-shaped body morphogenesis positive regulation of calcium ion import positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process in utero embryonic development kidney development tissue homeostasis nitrogen compound metabolic process response to organic cyclic compound phosphorylation hemopoiesis adrenal gland development response to lipid intracellular signal transduction skeletal system morphogenesis smooth muscle tissue development regulation of peptidyl-tyrosine phosphorylation metanephric glomerulus morphogenesis protein phosphorylation chemotaxis transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development cardiac vascular smooth muscle cell differentiation
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