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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Highest antigen sequence identity to the following orthologs: Mouse- 98%, Rat- 97%.
Sequence of this protein is as follows: YGIRGFPTIK IFQKGESPVD YDGGRTRSDI VSRALDLFSD NAPPPELLEI INEDIAKRTC EEHQLCVVAV LPHILDTGAA GRNSYLEVLL KLA
P5 is a novel protein that was originally identified in humans. Functionally, P5 has been shown to have peptide binding ability and chaperone activity specific to certain proteins. P5 shares several structural similarities to PDI, an important protein of the ER. The deduced amino acid sequence of P5 shows that it contains the ER retention signal KDEL. P5 also contains two CXXC-like motifs, a motif responsible for oxidoreductase activity. These two CXXC motifs are found on the N- and C-terminus of the protein, one at each end. Studies suggest that the N-terminal CXXC motif is more important than the second for isomerase activity. Contrary to most of the PDI-like proteins, P5 is not stress-inducible.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Endoplasmic reticulum protein 5; ER protein 5; Protein disulfide isomerase P5; Protein disulfide-isomerase A6; Thioredoxin domain-containing protein 7
基因别名: ERP5; P5; PDIA6; TXNDC7
Entrez Gene ID: (Human) 10130