Invitrogen

PDX1 Polyclonal Antibody

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1 篇参考文献
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说明书
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问题与答案
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说明书
实验方案
问题与答案
技术支持
PDX1 Polyclonal Antibody

产品信息

PA5-78024

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

其他PubMed (Misc)

-
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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human PDX1. The exact sequence is proprietary.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.29 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2736337

产品详细信息

Positive Control: Jurkat, Raji, NCI-H929, mouse liver, rat liver, AsPC-1, mouse pancreas

Predicted Reactivity: Dog (100%), Pig (100%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: DLDBP; E3BP; Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; insulin promotor factor 1; Insulin upstream factor 1; IPF-1; Islet/duodenum homeobox 1; Islet/duodenum homeobox-1; IUF-1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; pancreatic-duodenal homeobox factor 1; PDHX; PDX-1; somatostatin transactivating factor 1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1

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基因别名: GSF; IDX-1; Idx1; IPF-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; PDX1; STF-1; STF1

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UniProt ID: (Human) P52945, (Rat) P52947, (Mouse) P52946

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Entrez Gene ID: (Human) 3651, (Rat) 29535, (Mouse) 18609

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor binding protein complex binding protein heterodimerization activity DNA binding protein binding sequence-specific DNA binding
参与通路
negative regulation of transcription from RNA polymerase II promoter liver development type B pancreatic cell differentiation glucose metabolic process transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter smoothened signaling pathway nitric oxide mediated signal transduction central nervous system development positive regulation of cell proliferation negative regulation of cell proliferation response to wounding response to glucose response to iron(II) ion response to chlorate organ senescence positive regulation of cell death response to organic cyclic compound morphogenesis of embryonic epithelium insulin secretion cell differentiation pancreas development exocrine pancreas development endocrine pancreas development organ regeneration response to nutrient levels positive regulation of insulin secretion response to vitamin response to lipid response to cytokine response to nicotine positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell proliferation response to drug glucose homeostasis response to leucine response to alkaloid positive regulation of DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract development stem cell differentiation response to glucocorticoid detection of glucose transdifferentiation response to fatty acid negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of type B pancreatic cell apoptotic process multicellular organism development regulation of gene expression generation of precursor metabolites and energy organ morphogenesis
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