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Immunogen sequence: KVPVNKLAAA VSNFGYDLYR VRSSMSPTTN VLLSPLSVAT ALSALSLGAE QRTESIIHRA LYYDLISSPD IHGTYKELLD TVTAPQKNLK SASRIVFEKK LRIKSSFVAP LEKSYGTRPR VLTGNPRLDL QEINNWVQAQ MKGKL
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cell proliferation-inducing gene 35 protein; EPC 1; EPC-1; EPC1; PEDF; PIG 35; Pigment epithelium-derived factor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Serpin F1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; SERPINF 1; sserpin family F member 1; testis tissue sperm-binding protein Li 70n
基因别名: EPC-1; OI12; OI6; PEDF; PIG35; SERPINF1
UniProt ID: (Human) P36955
Entrez Gene ID: (Human) 5176