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Invitrogen
PF4 Polyclonal Antibody
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Product Details
PA5-120547
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 32-101 of human CXCL4/PF4 (NP_002610.1).
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Amount
95 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Mouse spleen, Rat lung, Rat spleen, Rat plasma.
Immunogen sequence: EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES
Target Information
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; Iroplact; Oncostatin-A; PF-4; PF4; Platelet factor 4
Gene Aliases: CXCL4; PF-4; PF4; Pf4a; RATPF4A; SCYB4
UniProt ID: (Human) P02776, (Rat) P06765, (Mouse) Q9Z126
Entrez Gene ID: (Human) 5196, (Rat) 360918, (Mouse) 56744
monocyte chemotaxis
chemotaxis
defense response
inflammatory response
immune response
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
negative regulation of angiogenesis
cytokine-mediated signaling pathway
platelet activation
negative regulation of blood coagulation
neutrophil chemotaxis
leukocyte chemotaxis
killing of cells of other organism
positive regulation of tumor necrosis factor production
regulation of cell proliferation
defense response to protozoan
negative regulation of MHC class II biosynthetic process
positive regulation of macrophage differentiation
negative regulation of megakaryocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
killing by host of symbiont cells
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to lipopolysaccharide
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of leukocyte chemotaxis
protein complex assembly
G-protein coupled receptor signaling pathway
positive regulation of cAMP metabolic process
response to lipopolysaccharide
positive regulation of cAMP-mediated signaling
negative regulation of cytolysis
chemokine-mediated signaling pathway
cell chemotaxis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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