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Invitrogen
PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (17C3)
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PGC1 alpha/beta Antibody (MA572607) in WB
Western blot analysis of PGC1 alpha/beta in Kidney and Ovary lysates (25 µg/lane). Samples were incubated with PGC1 alpha/beta Recombinant Monoclonal (Product # MA572607) at 1:1,000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at room temperature for 60 min.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA572607
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
17C3
抗原
KLH conjugated synthetic peptide derived from human PGC1 alpha.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERR ligand 1; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; PGC-1; pgc-1 alpha; pgc-1 beta; PGC-1-alpha; PGC-1-beta; PGC-1alpha; PPAR gamma coactivator 1alpha variant form-1; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-alpha; PPAR-gamma coactivator 1-beta; PPARGC-1-alpha; PPARGC-1-beta; Ppargc1a-vf1; transcriptional coactivator; unnamed protein product
基因别名: 4631412G21Rik; A830037N07Rik; Gm11133; LRPGC1; Perc; PGC-1; Pgc-1alpha; PGC-1beta; PGC-1beta/ERRL1; PGC-1v; Pgc1; PGC1beta; Pgco1; PGCvf; PGCvf-1; PGCvf1; PPARGC-1-alpha; PPARGC-1-beta; Ppargc1
UniProt ID: (Mouse) O70343, (Rat) Q9QYK2, (Mouse) Q8VHJ7, (Rat) Q811R2
Entrez Gene ID: (Mouse) 19017, (Rat) 83516, (Mouse) 170826, (Rat) 291567
nucleic acid binding
DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
RNA binding
protein binding
ligand-dependent nuclear receptor binding
estrogen receptor binding
chromatin DNA binding
ubiquitin protein ligase binding
peroxisome proliferator activated receptor binding
alpha-tubulin binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
lncRNA binding
promoter-specific chromatin binding
AF-2 domain binding
negative regulation of protein phosphorylation
response to dietary excess
gluconeogenesis
regulation of transcription, DNA-templated
mitochondrion organization
positive regulation of gene expression
response to activity
response to muscle activity
negative regulation of smooth muscle cell migration
respiratory electron transport chain
developmental process
circadian regulation of gene expression
cellular response to oxidative stress
regulation of circadian rhythm
negative regulation of neuron apoptotic process
positive regulation of gluconeogenesis
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
negative regulation of smooth muscle cell proliferation
multicellular organismal homeostasis
adipose tissue development
cellular response to follicle-stimulating hormone stimulus
cellular response to transforming growth factor beta stimulus
negative regulation of mitochondrial fission
energy homeostasis
cellular response to thyroid hormone stimulus
positive regulation of cold-induced thermogenesis
positive regulation of glomerular visceral epithelial cell apoptotic process
positive regulation of vascular smooth muscle cell proliferation
positive regulation of progesterone biosynthetic process
negative regulation of receptor activity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
intracellular estrogen receptor signaling pathway
positive regulation of osteoclast differentiation
response to nutrient
response to glucocorticoid
response to cAMP
response to reactive oxygen species
mitophagy
response to hypoxia
response to ischemia
galactose metabolic process
response to xenobiotic stimulus
response to fructose
skeletal muscle atrophy
response to electrical stimulus involved in regulation of muscle adaptation
fatty acid oxidation
cerebellum development
forebrain development
response to nutrient levels
cellular response to potassium ion
response to starvation
response to leucine
response to morphine
response to electrical stimulus
cellular response to lipopolysaccharide
cellular response to nitrite
cellular response to caffeine
cellular response to fructose stimulus
cellular response to glucose stimulus
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to estradiol stimulus
cellular response to fatty acid
cellular response to hypoxia
response to epinephrine
response to norepinephrine
response to thyroid hormone
response to dehydroepiandrosterone
cellular response to ionomycin
cellular response to resveratrol
response to methionine
adaptive thermogenesis
response to hypobaric hypoxia
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