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Invitrogen
PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (17C3)
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PGC1 alpha/beta Antibody (MA572607) in WB
Western blot analysis of PGC1 alpha/beta in Kidney and Ovary lysates (25 µg/lane). Samples were incubated with PGC1 alpha/beta Recombinant Monoclonal (Product # MA572607) at 1:1,000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at room temperature for 60 min.
产品信息
MA572607
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
17C3
抗原
KLH conjugated synthetic peptide derived from human PGC1 alpha.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERR ligand 1; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; pgc-1 alpha; pgc-1 beta; PGC-1-alpha; PGC-1-beta; PGC-1alpha; Pgc-1alphaa; PGC-1beta; PGC-1beta/ERRL1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-alpha; PPAR-gamma coactivator 1-beta; PPARGC-1-alpha; PPARGC-1-beta
基因别名: 4631412G21Rik; A830037N07Rik; ENSMUSG00000079510; Errl1; Gm11133; Perc; PGC-1; Pgc-1alpha; PGC-1v; Pgc1; Pgc1a; Pgc1b; PGC1beta; Pgco1; Ppargc1; Ppargc1a; Ppargc1b
UniProt ID: (Mouse) O70343, (Rat) Q9QYK2, (Rat) Q811R2, (Mouse) Q8VHJ7
Entrez Gene ID: (Mouse) 19017, (Rat) 83516, (Rat) 291567, (Mouse) 170826
nucleotide binding
RNA polymerase II transcription cofactor activity
nucleic acid binding
DNA binding
chromatin binding
transcription coactivator activity
RNA binding
protein binding
transcription factor binding
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
chromatin DNA binding
ubiquitin protein ligase binding
sequence-specific DNA binding
molecular_function
estrogen receptor binding
receptor activator activity
AF-2 domain binding
transcription cofactor
response to dietary excess
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
mitochondrion organization
positive regulation of mitochondrion organization
response to muscle activity
negative regulation of smooth muscle cell migration
respiratory electron transport chain
positive regulation of cellular metabolic process
circadian regulation of gene expression
cellular response to oxidative stress
regulation of circadian rhythm
negative regulation of neuron apoptotic process
cellular respiration
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
rhythmic process
positive regulation of smooth muscle cell proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron death
positive regulation of cellular respiration
positive regulation of mitochondrial DNA metabolic process
positive regulation of muscle tissue development
negative regulation of receptor activity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of energy homeostasis
positive regulation of ATP biosynthetic process
response to hypoxia
galactose metabolic process
androgen metabolic process
response to cold
response to organic cyclic compound
response to activity
response to nutrient levels
response to statin
response to drug
response to starvation
response to leucine
flavone metabolic process
cellular response to nitrite
cellular response to tumor necrosis factor
cellular response to fatty acid
cellular response to hypoxia
response to epinephrine
response to norepinephrine
cellular response to thyroid hormone stimulus
ossification
transcription from mitochondrial promoter
actin filament organization
positive regulation of alkaline phosphatase activity
intracellular estrogen receptor signaling pathway
cellular response to reactive oxygen species
positive regulation of phosphorylation
positive regulation of osteoclast differentiation
positive regulation of bone resorption
negative regulation of transcription, DNA-templated
response to glucocorticoid
response to cAMP
bone trabecula formation
positive regulation of receptor activity
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